Breast cancer proliferative activity: is it the source of serum free DNA?

To study the relationship between serum DNA and breast cancer proliferative activity, then compare the diagnostic and prognostic values of serum DNA, TPS and CEA. A total of 100 breast cancer patients before surgery and 50 apparently healthy controls were analyzed for serum DNA, TPS and CEA. Serum DNA levels were nonsignificantly correlated with serum TPS levels. Serum DNA, TPS and CEA levels were significantly higher in patients than controls. Using ROC curve analysis, serum TPS and DNA had the highest AUC compared to serum CEA. Neither serum TPS, DNA nor CEA correlated with breast cancer clinicopathological data. Only serum CEA was significantly correlated with patients' disease-free survival. Neither Breast cancer mass nor proliferative activity is the source of serum free DNA. Serum TPS is superior to DNA and CEA as a diagnostic marker for breast cancer. Only preoperative serum CEA has a prognostic role in predicting relapse of breast cancer patients, but not serum TPS or DNA

Association of body mass index and serum adipocytokines with breast cancer risk in Egyptian premenopausal females in Alexandria

To analyze the association between obesity and breast cancer risk among premenopausal females in Alexandria, Egypt. Blood samples were collected from 30 newly diagnosed, histologically-confirmed breast cancer patients before surgery and 30 age-and menstrual status-matched healthy controls. Standardized questionnaires concerning age at presentation, age at menarche, parity, body mass index [BMI], electromagnetic radiation [EMR] exposure, lactation and oral contraceptive intake were completed by the same researcher. Serum levels of leptin and adiponectin were assayed simultaneously. Univariate analysis showed that EMR exposure, age at presentation>30 years, nulliparity, artificial lactation and increased BMI were significantly associated with breast cancer risk [p<0.05]. Multivariate logistic regression analysis showed that EMR exposure [p=0.003] and age at presentation>30 years [p=0.02] both were significant independent risk factors. EMR exposure and female age>30 years are the most important risk factors in predicting breast cancer in Egyptian premenopausal females so we recommend them to do periodic breast self-examination specially during the fourth decade of life and to avoid overexposure to EMR